by rmsgrey
I've only played a couple of months of Season 2, so there may be more backlinks to come, but so far it's carefully vague about how the backstory actually connects - there are elements that are reminiscent of events from Season 1, but it all happens long enough afterwards that, unless you've played Season 1 and know how it turned out, you can't tell whether it's that Season 1 ended in an apocalypse, or that Season 1 ended with the world saved, and then another plague a few years later did trigger the apocalypse.
Season 2's setting is very-late apocalypse - the last desperate survivors trying to find a way for humanity to survive following on from an apocalypse like the one threatened by Season 1.
As for strategy:
- Embrace uncertainty. Every month changes something about the game, so what works well for one game may not be the best idea for the next - experiment with different options and change up your strategies rather than trying to come up with one ideal strategy that will work every time.
- Play each game as it comes, but consider long-term consequences. For example, in Season 1, you start the campaign with the ability to make up to two Research Stations constructed during a given game permanent. It makes sense to put some effort into putting one or two Research Stations in carefully chosen cities so they can be made permanent, where in regular Pandemic you'd be happy to drop one wherever is convenient.
- Make short-term choices based on what you know now rather than trying to plan too far ahead - if a choice gives you a noticeable benefit for the next couple of months before being made irrelevant by changing rules, then that's enough to justify it. The game may trick you into doing things you'll then have to undo later, but it generally pays off.
- Pay attention to the plot - that will give you hints about what you should be focusing on - either which optional objectives to prioritise, or what is worth setting as a personal goal.